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NEORAL (CYCLOSPORINE) CAPSULES AND ORAL SOLUTION: INFORMATION FOR PATIENTS

Patients should be advised that any change of cyclosporine formulation should be made cautiously and only under physician supervision because it may result in the need for a change in dosage.

Patients should be informed of the necessity of repeated laboratory tests while they are receiving Neoral (Cyclosporine) solution and capsules. Patients should be advised of the potential risks during pregnancy and informed of the increased risk of neoplasia. Patients should also be informed of the risk of hypertension and renal dysfunction.

Patients should be advised that during treatment with cyclosporine, vaccination may be less effective and the use of live attenuated vaccines should be avoided.

Patients should be given careful dosage instructions. Neoral Oral Solution (cyclosporine oral solution, USP) should be diluted, preferably with orange or apple juice that is at room temperature. The combination of Neoral Oral Solution (modified cyclosporine oral solution, USP) with milk can be unpalatable.

Patients should be advised to take Neoral on a consistent schedule with regard to time of day and relation to meals. Grapefruit and grapefruit juice affect metabolism, increasing blood concentration of cyclosporine, thus should be avoided.

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