Buy Cyclosporine (Neoral, Atopica, Restasis) online

Buy Atopica, Neoral, Restasis (Cyclosporine) ophthalmic and immunosuppressant medication
Cheap qualitative Cyclosporine eye drops 0.05% 3 ml, capsules 25 mg, 50 mg, 100 mg online



HOW AND WHERE TO BUY CYCLOSPORINE (NEORAL, RESTASIS, ATOPICA) 25 MG, 50 MG, 100 MG CAPSULES, 0.05% 3 ML OPHTHALMIC SOLUTION ONLINE:

NEORAL (CYCLOSPORINE) CAPSULES AND ORAL SOLUTION: PRESCRIBING INFORMATION

DESCRIPTION

Neoral is an oral formulation of cyclosporine that immediately forms a microemulsion in an aqueous environment.

Cyclosporine, the active principle in Neoral, is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It is produced as a metabolite by the fungus species Beauveria nivea.

Chemically, cyclosporine is designated as [R-[R*,R*-(E)]]-cyclic-(L-alanyl-D-alanyl-N-methyl-L-leucylN-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl.

Neoral Soft Gelatin Capsules

Modified Cyclosporine capsules, USP are available in 25 mg and 100 mg strengths.

Each 25 mg capsule contains:
cyclosporine 25 mg alcohol, USP dehydrated 11.9% v/v (9.5% wt/vol.)

Each 100 mg capsule contains:
cyclosporine 100 mg
alcohol, USP dehydrated 11.9% v/v (9.5% wt/vol.)

Inactive Ingredients: polyoxyl 40 hydrogenated castor oil NF, corn oil-mono-di-triglycerides, DL-Alphatocopherol USP, glycerol, gelatin NF, iron oxide black, propylene glycol USP, carmine, titanium dioxide USP, and other ingredients.

Neoral Oral Solution

Modified Cyclosporine oral solution, USP is available in 50 mL bottles.

Each mL contains:
cyclosporine 100 mg/mL
alcohol, USP dehydrated 11.9% v/v (9.5% wt/vol.)

Inactive Ingredients: corn oil-mono-di-triglycerides, polyoxyl 40 hydrogenated castor oil NF, propylene glycol USP, DL-Alpha Tocopherol USP.


CLINICAL PHARMACOLOGY

Neoral clinical pharmacology


PHARMACOKINETICS

Neoral pharmacokinetics


CLINICAL TRIALS

Neoral clinical trials


INDICATIONS AND USAGE

Neoral indications and usage


CONTRAINDICATIONS

General

Neoral (Cyclosporine) is contraindicated in patients with a hypersensitivity to cyclosporine or to any of the ingredients of the formulation.

Rheumatoid Arthritis

Rheumatoid arthritis patients with abnormal renal function, uncontrolled hypertension, or malignancies should not receive Neoral.

Psoriasis

Psoriasis patients who are treated with Neoral should not receive concomitant PUVA or UVB therapy, methotrexate or other immunosuppressive agents, coal tar or radiation therapy. Psoriasis patients with abnormal renal function, uncontrolled hypertension, or malignancies should not receive Neoral (Cyclosporine) capsules and oral solution.


WARNINGS

Neoral warnings


WARNINGS FOR TRANSPLANT

Neoral warnings for transplant


WARNINGS FOR PSORIASIS

Neoral warnings for psoriasis


PRECAUTIONS

Neoral precautions


SPECIAL PRECAUTIONS

Neoral special precautions


DRUG INTERACTIONS

Neoral drug interactions


NONCLINICAL TOXICOLOGY

Neoral nonclinical toxicology


USE IN SPECIFIC POPULATIONS

Neoral use in specific populations


ADVERSE REACTIONS FOR TRANSPLANTATION

Neoral adverse reactions for transplantation


ADVERSE REACTIONS FOR RHEUMATOID ARTHRITIS

Neoral adverse reactions for rheumatoid arthritis


ADVERSE REACTIONS FOR PSORIASIS

Neoral adverse reactions for psoriasis


OVERDOSAGE

There is a minimal experience with cyclosporine overdosage. Forced emesis and gastric lavage can be of value up to 2 hours after administration of Neoral. Transient hepatotoxicity and nephrotoxicity may occur which should resolve following drug withdrawal. Oral doses of cyclosporine up to 10 g (about 150 mg/kg) have been tolerated with relatively minor clinical consequences, such as vomiting, drowsiness, headache, tachycardia and, in a few patients, moderately severe, reversible impairment of renal function. However, serious symptoms of intoxication have been reported following accidental parenteral overdosage with cyclosporine in premature neonates. General supportive measures and symptomatic treatment should be followed in all cases of overdosage. Cyclosporine is not dialyzable to any great extent, nor is it cleared well by charcoal hemoperfusion. The oral dosage at which half of experimental animals are estimated to die is 31 times, 39 times, and > 54 times the human maintenance dose for transplant patients (6mg/kg; corrections based on body surface area) in mice, rats, and rabbits.


DOSAGE AND ADMINISTRATION

Neoral dosage and administration


DOSAGE AND ADMINISTRATION FOR TRANSPLANT

Neoral dosage and administration for transplant


DOSAGE AND ADMINISTRATION FOR PSORIASIS

Neoral dosage and administration for psoriasis


HOW SUPPLIED

Neoral Soft Gelatin Capsules (Cyclosporine capsules, USP):

25 mg

Oval, blue-gray imprinted in red, "NEORAL" over "25 mg." Packages of 30 unit-dose blisters.

100 mg

Oblong, blue-gray imprinted in red, "NEORAL" over "100 mg." Packages of 30 unit-dose blisters.

Store and Dispense

In the original unit-dose container at controlled room temperature 68°-77°F (20°-25°C).

Neoral Oral Solution (cyclosporine oral solution, USP)

A clear, yellow liquid supplied in 50 mL bottles containing 100 mg/mL.

Store and Dispense

In the original container at controlled room temperature 68°-77°F (20°-25°C). Do not store in the refrigerator. Once opened, the contents must be used within two months. At temperatures below 68°F (20°C) the solution may gel; light flocculation or the formation of a light sediment may also occur. There is no impact on product performance or dosing using the syringe provided. Allow to warm to room temperature 77°F (25°C) to reverse these changes.

Manufactured and distributed by Novartis pharmaceutical company and its divisions.

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